BOTOX Cosmetic is a quick 10-minute treatment that works beneath the surface and temporarily reduces the underlying muscle activity that causes moderate to severe frown lines, crow’s feet and forehead lines in adults – to help them look better Botox Cosmetic (botulinum toxin type A) blocks neuromuscular transmission by binding to acceptor sites on motor nerve terminals, entering the nerve terminals, and inhibiting the release of acetylcholine. he drug works by blocking nerve impulses to relax the contraction of the two major forehead muscles. These contractions are the cause vertical wrinkles between the eyebrows. Following treatment with Botox Cosmetic, improved appearance can be seen as early as one to two days, and the effects can last up to 6 months.